Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols

Joseph R. Lizza, Gustavo Moura-Letts

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.

Original languageEnglish (US)
Article numberss-2016-m0690-op
Pages (from-to)1231-1242
Number of pages12
JournalSynthesis (Germany)
Volume49
Issue number6
DOIs
StatePublished - Mar 15 2017

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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