Short tandem repeat polymorphism linkage studies in a new family with X- linked mental retardation (MRX20)

A. Lazzarini, E. S. Stenroos, T. Lehner, V. McKoy, B. Gold, Michael Mccormack, C. S. Reid, J. Ott, W. G. Johnson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume57
Issue number4
DOIs
StatePublished - Jul 10 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

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