Short tandem repeat polymorphism linkage studies in a new family with X- linked mental retardation (MRX20)

A. Lazzarini; E. S. Stenroos; T. Lehner; V. McKoy; B. Gold; M. K. McCormack; C. S. Reid; J. Ott; W. G. Johnson

doi:10.1002/ajmg.1320570407

Short tandem repeat polymorphism linkage studies in a new family with X- linked mental retardation (MRX20)

A. Lazzarini, E. S. Stenroos, T. Lehner, V. McKoy, B. Gold, M. K. McCormack, C. S. Reid, J. Ott, W. G. Johnson

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.

Original language	English (US)
Pages (from-to)	552-557
Number of pages	6
Journal	American Journal of Medical Genetics
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.1320570407
State	Published - 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics(clinical)

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abstract = "A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.",

author = "A. Lazzarini and Stenroos, {E. S.} and T. Lehner and V. McKoy and B. Gold and McCormack, {M. K.} and Reid, {C. S.} and J. Ott and Johnson, {W. G.}",

year = "1995",

doi = "10.1002/ajmg.1320570407",

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T1 - Short tandem repeat polymorphism linkage studies in a new family with X- linked mental retardation (MRX20)

AU - Lazzarini, A.

AU - Stenroos, E. S.

AU - Lehner, T.

AU - McKoy, V.

AU - Gold, B.

AU - McCormack, M. K.

AU - Reid, C. S.

AU - Ott, J.

AU - Johnson, W. G.

PY - 1995

Y1 - 1995

N2 - A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.

AB - A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.

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AN - SCOPUS:0029067447

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JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

IS - 4

ER -

Short tandem repeat polymorphism linkage studies in a new family with X- linked mental retardation (MRX20)

Abstract

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