TY - JOUR
T1 - Salivary cortisol
T2 - A practical method for evaluation of adrenal function
AU - Kahn, Jean Pierre
AU - Rubinow, David R.
AU - Davis, Candace L.
AU - Kling, Mitchell
AU - Post, Robert M.
PY - 1988/2/15
Y1 - 1988/2/15
N2 - Salivary cortisol represents a simple, noninvasive, stress-free measure that can greatly facilitate the longitudinal study of hypothalamic-pituitary-adrenal axis activity in patients with psychiatric disorders. By means of a slight modification of a commercially available radioimmunoassay kit, we studied the stability of salivary cortisol under different conditions, as well as the relationship between plasma and salivary cortisol under basal circadian conditions and following stimulation (CRH) and suppression (dexamethasone). We observed that salivary cortisol was quite stable at room temperature without centrifugation and that salivary and plasma cortisol values were highly correlated. Additionally, we observed a close correspondence in circadian and ultradian fluctuations in salivary and plasma cortisol. The salivary cortisol response to ovine and human CRH was similar to that observed with plasma cortisol, but was greater in magnitude. Finally, employing a plasma criterion as the standard, salivary measures identified 48% of the nonsuppressed Dexamethasone Suppression Tests (DSTs) and 97% of the suppressed DSTs.
AB - Salivary cortisol represents a simple, noninvasive, stress-free measure that can greatly facilitate the longitudinal study of hypothalamic-pituitary-adrenal axis activity in patients with psychiatric disorders. By means of a slight modification of a commercially available radioimmunoassay kit, we studied the stability of salivary cortisol under different conditions, as well as the relationship between plasma and salivary cortisol under basal circadian conditions and following stimulation (CRH) and suppression (dexamethasone). We observed that salivary cortisol was quite stable at room temperature without centrifugation and that salivary and plasma cortisol values were highly correlated. Additionally, we observed a close correspondence in circadian and ultradian fluctuations in salivary and plasma cortisol. The salivary cortisol response to ovine and human CRH was similar to that observed with plasma cortisol, but was greater in magnitude. Finally, employing a plasma criterion as the standard, salivary measures identified 48% of the nonsuppressed Dexamethasone Suppression Tests (DSTs) and 97% of the suppressed DSTs.
UR - http://www.scopus.com/inward/record.url?scp=0023828813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023828813&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(88)90284-3
DO - 10.1016/0006-3223(88)90284-3
M3 - Article
C2 - 3257706
AN - SCOPUS:0023828813
SN - 0006-3223
VL - 23
SP - 335
EP - 349
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -