Rutile Promoted Synthesis of Sulfonylamidonitriles from Simple Aldehydes and Sulfonamides

Nicholas V. Costantini, Alex D. Bates, Graham J. Haun, Natasha M. Chang, Gustavo Moura-Letts

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations


    We report the first rutile-promoted synthesis of sulfonylamidonitriles from aldehydes and sulfonamides with NaCN in water. This transformation has proven to work for a variety of aliphatic and aromatic aldehydes with excellent yields. The scope also extends to a variety of substituted sulfonamides. Rutile can be easily recycled and reused without significant reaction erosion. The benign nature of rutile and its natural abundance highlights this transformation as a model green reaction.

    Original languageEnglish (US)
    Pages (from-to)1906-1911
    Number of pages6
    JournalACS Sustainable Chemistry and Engineering
    Issue number4
    StatePublished - Apr 4 2016

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Environmental Chemistry
    • Chemical Engineering(all)
    • Renewable Energy, Sustainability and the Environment


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