TY - JOUR
T1 - Role of the RNA polymerase sigma subunit in transcription initiation
AU - Borukhov, Sergei
AU - Severinov, Konstantin
N1 - Funding Information:
Work in KS laboratory is supported by NIH grants GM59292 and GM64530. Work in SB laboratory was supported by NIH grant NIH 2RO1GM54098-06A1. We thank Drs. M. Barker and K. Adelman for careful reading of the manuscript.
PY - 2002/11
Y1 - 2002/11
N2 - In bacteria, σ subunits direct the catalytically competent RNA polymerase core enzyme to promoters. Recent advances in our understanding of bacterial RNA polymerase reveal that σ subunits are intimately involved in all aspects of transcription initiation including promoter location, promoter melting, initiation of RNA synthesis, abortive initiation and promoter escape.
AB - In bacteria, σ subunits direct the catalytically competent RNA polymerase core enzyme to promoters. Recent advances in our understanding of bacterial RNA polymerase reveal that σ subunits are intimately involved in all aspects of transcription initiation including promoter location, promoter melting, initiation of RNA synthesis, abortive initiation and promoter escape.
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U2 - 10.1016/S0923-2508(02)01368-2
DO - 10.1016/S0923-2508(02)01368-2
M3 - Review article
C2 - 12455702
AN - SCOPUS:0036840677
SN - 0923-2508
VL - 153
SP - 557
EP - 562
JO - Research in Microbiology
JF - Research in Microbiology
IS - 9
ER -