Role of the RNA polymerase sigma subunit in transcription initiation

Sergei Borukhov, Konstantin Severinov

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


In bacteria, σ subunits direct the catalytically competent RNA polymerase core enzyme to promoters. Recent advances in our understanding of bacterial RNA polymerase reveal that σ subunits are intimately involved in all aspects of transcription initiation including promoter location, promoter melting, initiation of RNA synthesis, abortive initiation and promoter escape.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalResearch in Microbiology
Issue number9
StatePublished - Nov 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology


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