Role of the conformational rigidity in the design of biomimetic antimicrobial compounds

Andrey Ivankin, Liran Livne, Amram Mor, Gregory A. Caputo, William F. Degrado, Mati Meron, Binhua Lin, David Gidalevitz

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

When structural flexibility is a plus: A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been established using liquid surface X-ray scattering techniques. Results indicate that the modes of interaction of flexible and conformationally restrained antimicrobials with the bacterial membranes are different (see picture).

Original languageEnglish (US)
Pages (from-to)8462-8465
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number45
DOIs
StatePublished - Nov 2 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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