TY - GEN
T1 - Role of plasma membrane calcium ATPase isoform 2 in neuronal function in the cerebellum and spinal cord
AU - Kurnellas, Michael P.
AU - Lee, Amanda K.
AU - Szczepanowski, Karolynn
AU - Elkabes, Stella
PY - 2007/3
Y1 - 2007/3
N2 - The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood. We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2-null mice and to abnormal changes in molecular pathways in Purkinje cells. Thus, PMCA2 may have unique, nonredundant functions in spinal cord and cerebellar neurons. Our results suggest that anomalous alterations in PMCA2 activity or expression may induce pathology in some neuronal populations, a possibility that will be the focus of future investigations.
AB - The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood. We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2-null mice and to abnormal changes in molecular pathways in Purkinje cells. Thus, PMCA2 may have unique, nonredundant functions in spinal cord and cerebellar neurons. Our results suggest that anomalous alterations in PMCA2 activity or expression may induce pathology in some neuronal populations, a possibility that will be the focus of future investigations.
UR - https://www.scopus.com/pages/publications/34248562442
UR - https://www.scopus.com/pages/publications/34248562442#tab=citedBy
U2 - 10.1196/annals.1387.025
DO - 10.1196/annals.1387.025
M3 - Conference contribution
C2 - 17446469
AN - SCOPUS:34248562442
SN - 1573316490
SN - 9781573316491
T3 - Annals of the New York Academy of Sciences
SP - 287
EP - 291
BT - Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion
PB - Blackwell Publishing Inc.
ER -