Role of Gambogic Acid in Chemosensitization of Cancer

Vijay P. Kale, Patrick J. Gilhooley, Sangita Phadtare, Ali Nabavizadeh, Manoj K. Pandey

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Mother Nature has blessed us with a variety of natural compounds rich in anti-inflammatory and anti-tumor properties. In the past three decades, plant-derived natural compounds, popularly referred to as nutraceuticals, have received a lot of attention because they are economic, bioavailable, safe, and lethal to cancers. One of noteworthy nutraceuticals is gambogic acid (GA). GA that is derived from gamboge resins secreted by a plant known as Garcinia hanburyi. Extensive preclinical studies have strongly suggested that GA possesses anti-cancer properties against a variety of malignancies including solid and hematologic cancers. GA exerts its effects on cancer cells through several different mechanisms. Interestingly, normal human cells were found to be resistant to GA, suggesting that this nutraceutical has tremendous therapeutic values. Chemoresistance has been recognized as one of the largest hurdles facing anti-cancer regimens. Therefore, researchers have continued to search for potent chemosensitizers. This chapter focuses on the chemosensitizing properties of GA, mechanisms through which GA exerts anti-proliferative and apoptotic effects in cancer. GA sensitizes acute myeloid leukemia (AML), gastric cancer, lung cancer, ovarian cancer, prostate cancer, pancreatic cancer, renal carcinoma, and multiple myeloma (MM). GA acts synergistically with many chemotherapeutic agents including adriamycin, cisplatin, doxorubicin, 5-fluorouracil (5-FU), gefitinib, and proteasome inhibitors. Overall, in vitro and studies using animal models demonstrate that GA can be used to sensitize tumors to chemotherapy. Nonetheless, a clinical trial is needed in order to fully delineate the utility of this nutraceutical in human cancers.

Original languageEnglish (US)
Title of host publicationRole of Nutraceuticals in Cancer Chemosensitization
Subtitle of host publicationVolume 2
PublisherElsevier
Pages151-167
Number of pages17
Volume2
ISBN (Electronic)9780128123737
ISBN (Print)9780128123744
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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