TY - JOUR
T1 - RNA remodeling and gene regulation by cold shock proteins
AU - Phadtare, Sangita
AU - Severinov, Konstantin
N1 - Funding Information:
tion phase. In a pnp mutant, expression of CspA homologs was This work was supported by NIH RO3 Grant 76900 to S.P. and significantly prolonged upon cold shock.87,116 PNPase has been G.M. “RO1 64530, Russian Academy of Sciences Presidium shown to be associated with endonuclease RNase E and other Molecular and Cell Biology Program grant and Federal Program proteins in the RNA degradosome.117-119 In vitro, PNPase cata-“Scientific and pedagogical cadre of innovative Russia” 2009-lyzes phosphorolytic degradation of RNA, releasing nucleoside 2013,” State contract 02.740.11.0771 to K.S.
PY - 2010
Y1 - 2010
N2 - One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect cell growth at low temperature. Several cold shock proteins are produced to counteract these effects and thus allow cold acclimatization of the cell. The main RNA modulating cold shock proteins of E. coli can be broadly divided into two categories, (i) the CspA family proteins, which mainly affect the transcription and possibly translation at low temperature through their RNA chaperoning function and (ii) RNA helicases and exoribonucleases that stimulate RNA degradation at low temperature through their RNA unwinding activity.
AB - One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect cell growth at low temperature. Several cold shock proteins are produced to counteract these effects and thus allow cold acclimatization of the cell. The main RNA modulating cold shock proteins of E. coli can be broadly divided into two categories, (i) the CspA family proteins, which mainly affect the transcription and possibly translation at low temperature through their RNA chaperoning function and (ii) RNA helicases and exoribonucleases that stimulate RNA degradation at low temperature through their RNA unwinding activity.
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U2 - 10.4161/rna.7.6.13482
DO - 10.4161/rna.7.6.13482
M3 - Review article
C2 - 21045540
AN - SCOPUS:78751666283
SN - 1547-6286
VL - 7
SP - 788
EP - 795
JO - RNA Biology
JF - RNA Biology
IS - 6
ER -