Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation

Alan C. Rapraeger, Alson Krufka, Bradley B. Olwin

Research output: Contribution to journalArticlepeer-review

1243 Scopus citations

Abstract

Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell sigling.

Original languageEnglish (US)
Pages (from-to)1705-1708
Number of pages4
JournalScience
Volume252
Issue number5013
DOIs
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation'. Together they form a unique fingerprint.

Cite this