Relative potency of nitrovasodilators on human placental vessels from normal and preeclamptic pregnancies

C. González, M. A. Cruz, V. Gallardo, P. Miguel, Gonzalo Carrasco

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The relative potency of glyceryl trinitrate (GTN), sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) was determined in human placental arteries and veins from normotensive gestants and preeclamptic women. This study demonstrates that the potency of the three nitrovasodilators is similar in normal and preeclamptic pregnancies. GTN and SNP behave as strong vasodilators and were significantly more potent as relaxant of venous than arterial segments. Meanwhile, SNAP was 1 order of magnitude less potent than GTN and SNP and is equally effective in reducing induced tone in arterial or venous segments. These observations suggest that the placental vessels obtained from normotensive and preeclamptic gestants resulted equally sensitive to the relaxant effect of each nitric oxide donor drug, and nitrovasodilators appear to be an interesting option for further clinical research on the prevention and management of preeclampsia.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume43
Issue number4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Nitroglycerin
Nitroprusside
S-Nitroso-N-Acetylpenicillamine
Pregnancy
Nitric Oxide Donors
Pre-Eclampsia
Vasodilator Agents
Veins
Arteries
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

@article{39bbf7577cbc45e8bfec28d406efb0f5,
title = "Relative potency of nitrovasodilators on human placental vessels from normal and preeclamptic pregnancies",
abstract = "The relative potency of glyceryl trinitrate (GTN), sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) was determined in human placental arteries and veins from normotensive gestants and preeclamptic women. This study demonstrates that the potency of the three nitrovasodilators is similar in normal and preeclamptic pregnancies. GTN and SNP behave as strong vasodilators and were significantly more potent as relaxant of venous than arterial segments. Meanwhile, SNAP was 1 order of magnitude less potent than GTN and SNP and is equally effective in reducing induced tone in arterial or venous segments. These observations suggest that the placental vessels obtained from normotensive and preeclamptic gestants resulted equally sensitive to the relaxant effect of each nitric oxide donor drug, and nitrovasodilators appear to be an interesting option for further clinical research on the prevention and management of preeclampsia.",
author = "C. Gonz{\'a}lez and Cruz, {M. A.} and V. Gallardo and P. Miguel and Gonzalo Carrasco",
year = "1997",
month = "1",
day = "1",
doi = "10.1159/000291861",
language = "English (US)",
volume = "43",
pages = "219--224",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "4",

}

Relative potency of nitrovasodilators on human placental vessels from normal and preeclamptic pregnancies. / González, C.; Cruz, M. A.; Gallardo, V.; Miguel, P.; Carrasco, Gonzalo.

In: Gynecologic and Obstetric Investigation, Vol. 43, No. 4, 01.01.1997, p. 219-224.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relative potency of nitrovasodilators on human placental vessels from normal and preeclamptic pregnancies

AU - González, C.

AU - Cruz, M. A.

AU - Gallardo, V.

AU - Miguel, P.

AU - Carrasco, Gonzalo

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The relative potency of glyceryl trinitrate (GTN), sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) was determined in human placental arteries and veins from normotensive gestants and preeclamptic women. This study demonstrates that the potency of the three nitrovasodilators is similar in normal and preeclamptic pregnancies. GTN and SNP behave as strong vasodilators and were significantly more potent as relaxant of venous than arterial segments. Meanwhile, SNAP was 1 order of magnitude less potent than GTN and SNP and is equally effective in reducing induced tone in arterial or venous segments. These observations suggest that the placental vessels obtained from normotensive and preeclamptic gestants resulted equally sensitive to the relaxant effect of each nitric oxide donor drug, and nitrovasodilators appear to be an interesting option for further clinical research on the prevention and management of preeclampsia.

AB - The relative potency of glyceryl trinitrate (GTN), sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) was determined in human placental arteries and veins from normotensive gestants and preeclamptic women. This study demonstrates that the potency of the three nitrovasodilators is similar in normal and preeclamptic pregnancies. GTN and SNP behave as strong vasodilators and were significantly more potent as relaxant of venous than arterial segments. Meanwhile, SNAP was 1 order of magnitude less potent than GTN and SNP and is equally effective in reducing induced tone in arterial or venous segments. These observations suggest that the placental vessels obtained from normotensive and preeclamptic gestants resulted equally sensitive to the relaxant effect of each nitric oxide donor drug, and nitrovasodilators appear to be an interesting option for further clinical research on the prevention and management of preeclampsia.

UR - http://www.scopus.com/inward/record.url?scp=1842292771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842292771&partnerID=8YFLogxK

U2 - 10.1159/000291861

DO - 10.1159/000291861

M3 - Article

C2 - 9194618

AN - SCOPUS:1842292771

VL - 43

SP - 219

EP - 224

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 4

ER -