Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule

Susanne Wirth, Annelyse Vessaz, Claude Krummenacher, Frédéric Baribaud, Hans Acha-Orbea, Heidi Diggelmann

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

Original languageEnglish (US)
Pages (from-to)11172-11175
Number of pages4
JournalJournal of virology
Volume76
Issue number21
DOIs
StatePublished - Nov 2002

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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