Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule

Susanne Wirth; Annelyse Vessaz; Claude Krummenacher; Frédéric Baribaud; Hans Acha-Orbea; Heidi Diggelmann

doi:10.1128/JVI.76.21.11172-11175.2002

Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule

Susanne Wirth, Annelyse Vessaz, Claude Krummenacher, Frédéric Baribaud, Hans Acha-Orbea, Heidi Diggelmann

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

Original language	English (US)
Pages (from-to)	11172-11175
Number of pages	4
Journal	Journal of virology
Volume	76
Issue number	21
DOIs	https://doi.org/10.1128/JVI.76.21.11172-11175.2002
State	Published - Nov 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.76.21.11172-11175.2002

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abstract = "To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.",

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AU - Wirth, Susanne

AU - Vessaz, Annelyse

AU - Krummenacher, Claude

AU - Baribaud, Frédéric

AU - Acha-Orbea, Hans

AU - Diggelmann, Heidi

PY - 2002/11

Y1 - 2002/11

N2 - To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

AB - To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.

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ER -

Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule

Abstract

All Science Journal Classification (ASJC) codes

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