Reduction of Anthelmintic Drug (Methyl [1]carbamate-albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

Geoffrey N. Kamau, Zahilis Mazzochette, Helen K. Kahi, Amos Mugweru

Research output: Contribution to journalArticle

Abstract

Albendazole (ABZ) is a widely used anthelmintic drug for the treatment of parasitic worms and other diseases. The bulk electrolysis reduction reaction of albendazole (ABZ) was carried out in ammonium bromide-acetonitrile solution under stirring conditions. The reduction of albendazole at gold electrode gave three non-reversible waves. The average value of the electron transfer coefficient (nα) was found to be 0.505. The measured diffusion coefficient (D) had a value of 0.143×10−8 cm2 s−1. The bulk electrochemical reduction of ABZ products were characterized using liquid chromatography-mass spectroscopy. Three cyclic voltammetry reduction waves were observed using a gold electrode and three chromatographic peaks were observed using liquid chromatography- Mass spectrometry. The observed results suggested that the second and third reduction steps occurred at the sulfur functional group of albendazole.

Original languageEnglish (US)
Pages (from-to)2697-2702
Number of pages6
JournalElectroanalysis
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Electrochemistry

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