TY - JOUR
T1 - Rb, whi it's not just for metazoans anymore
AU - Cooper, K.
N1 - Funding Information:
I thank Randy Strich (UMDNJ) for his helpful comments on this manuscript and Curt Wittenberg (Scripps Institute) for sharing unpublished data. KFC is supported by ACS Grant # RSG0324901CCG.
PY - 2006/8/28
Y1 - 2006/8/28
N2 - The E2F family of heterodimeric transcription factors controls the expression of genes required in G1 for cell cycle progression. The retinoblastoma (Rb) family of pocket proteins which, upon binding to E2F, inhibit this complex from initiating transcription. Upon mitogen stimulation, this repression is relieved by hyperphosphorylation of Rb by the cyclin D Cdk4/6 complex. Initiation of the cell cycle in yeast is similar. The heterodimeric transcription factor SBF controls most G1-specific transcription. Its activation is dependent upon the removal of Whi5; a functional homolog of Rb. Similar to Rb, disassociation of Whi5 from SBF is controlled by G1 cyclin/Cdk-dependent phosphorylation. Although Rb and Whi5 play similar roles in regulating G1 gene expression, they exhibit no sequence homology. This review will discuss the difference and similarities between how these proteins play similar roles in controlling G1 progression.
AB - The E2F family of heterodimeric transcription factors controls the expression of genes required in G1 for cell cycle progression. The retinoblastoma (Rb) family of pocket proteins which, upon binding to E2F, inhibit this complex from initiating transcription. Upon mitogen stimulation, this repression is relieved by hyperphosphorylation of Rb by the cyclin D Cdk4/6 complex. Initiation of the cell cycle in yeast is similar. The heterodimeric transcription factor SBF controls most G1-specific transcription. Its activation is dependent upon the removal of Whi5; a functional homolog of Rb. Similar to Rb, disassociation of Whi5 from SBF is controlled by G1 cyclin/Cdk-dependent phosphorylation. Although Rb and Whi5 play similar roles in regulating G1 gene expression, they exhibit no sequence homology. This review will discuss the difference and similarities between how these proteins play similar roles in controlling G1 progression.
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U2 - 10.1038/sj.onc.1209630
DO - 10.1038/sj.onc.1209630
M3 - Review article
C2 - 16936741
AN - SCOPUS:33748031725
SN - 0950-9232
VL - 25
SP - 5228
EP - 5232
JO - Oncogene
JF - Oncogene
IS - 38
ER -