Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle

Thomas Stein, M. D. Schluter, R. E. Grindeland, M. M. Moran, L. A. Baer, C. E. Wade

Research output: Contribution to journalConference articlepeer-review

Abstract

A minor pathway for fatty acid oxidation is the cytosolic peroxisomal pathway. Thus, mrNA expression of most of the enzymes in this pathway are found to be reduced with hindlimb suspension (HLS). Since both the intra and extra-mitochondrial pathways for fatty acids are reduced it would seem that the regulatory step is prior to the point at which the two pathways diverge. The observations show that a principle factor in determining the atrophy induced fuel shift in muscle is the response of hormone sensitive lipase to the plasma substrate and endocrine environment.

Original languageEnglish (US)
Pages (from-to)357-358
Number of pages2
JournalEuropean Space Agency, (Special Publication) ESA SP
Issue number501
StatePublished - Sep 1 2002
Externally publishedYes
EventProceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden
Duration: Jun 2 2002Jun 7 2002

All Science Journal Classification (ASJC) codes

  • Aerospace Engineering
  • Space and Planetary Science

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