Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle

T. P. Stein; M. D. Schluter; R. E. Grindeland; M. M. Moran; L. A. Baer; C. E. Wade

Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle

T. P. Stein, M. D. Schluter, R. E. Grindeland, M. M. Moran, L. A. Baer, C. E. Wade

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Abstract

A minor pathway for fatty acid oxidation is the cytosolic peroxisomal pathway. Thus, mrNA expression of most of the enzymes in this pathway are found to be reduced with hindlimb suspension (HLS). Since both the intra and extra-mitochondrial pathways for fatty acids are reduced it would seem that the regulatory step is prior to the point at which the two pathways diverge. The observations show that a principle factor in determining the atrophy induced fuel shift in muscle is the response of hormone sensitive lipase to the plasma substrate and endocrine environment.

Original language	English (US)
Pages (from-to)	357-358
Number of pages	2
Journal	European Space Agency, (Special Publication) ESA SP
Issue number	501
State	Published - Sep 2002
Event	Proceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden Duration: Jun 2 2002 → Jun 7 2002

All Science Journal Classification (ASJC) codes

Aerospace Engineering
Space and Planetary Science

Cite this

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title = "Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle",

abstract = "A minor pathway for fatty acid oxidation is the cytosolic peroxisomal pathway. Thus, mrNA expression of most of the enzymes in this pathway are found to be reduced with hindlimb suspension (HLS). Since both the intra and extra-mitochondrial pathways for fatty acids are reduced it would seem that the regulatory step is prior to the point at which the two pathways diverge. The observations show that a principle factor in determining the atrophy induced fuel shift in muscle is the response of hormone sensitive lipase to the plasma substrate and endocrine environment.",

author = "Stein, {T. P.} and Schluter, {M. D.} and Grindeland, {R. E.} and Moran, {M. M.} and Baer, {L. A.} and Wade, {C. E.}",

year = "2002",

month = sep,

language = "English (US)",

pages = "357--358",

journal = "European Space Agency, (Special Publication) ESA SP",

issn = "0379-6566",

publisher = "European Space Agency",

number = "501",

note = "Proceedings of the European Symposium on Life in Space for Life on Earth ; Conference date: 02-06-2002 Through 07-06-2002",

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TY - JOUR

T1 - Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle

AU - Stein, T. P.

AU - Schluter, M. D.

AU - Grindeland, R. E.

AU - Moran, M. M.

AU - Baer, L. A.

AU - Wade, C. E.

PY - 2002/9

Y1 - 2002/9

N2 - A minor pathway for fatty acid oxidation is the cytosolic peroxisomal pathway. Thus, mrNA expression of most of the enzymes in this pathway are found to be reduced with hindlimb suspension (HLS). Since both the intra and extra-mitochondrial pathways for fatty acids are reduced it would seem that the regulatory step is prior to the point at which the two pathways diverge. The observations show that a principle factor in determining the atrophy induced fuel shift in muscle is the response of hormone sensitive lipase to the plasma substrate and endocrine environment.

AB - A minor pathway for fatty acid oxidation is the cytosolic peroxisomal pathway. Thus, mrNA expression of most of the enzymes in this pathway are found to be reduced with hindlimb suspension (HLS). Since both the intra and extra-mitochondrial pathways for fatty acids are reduced it would seem that the regulatory step is prior to the point at which the two pathways diverge. The observations show that a principle factor in determining the atrophy induced fuel shift in muscle is the response of hormone sensitive lipase to the plasma substrate and endocrine environment.

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UR - http://www.scopus.com/inward/citedby.url?scp=0036770988&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0036770988

SN - 0379-6566

SP - 357

EP - 358

JO - European Space Agency, (Special Publication) ESA SP

JF - European Space Agency, (Special Publication) ESA SP

IS - 501

T2 - Proceedings of the European Symposium on Life in Space for Life on Earth

Y2 - 2 June 2002 through 7 June 2002

ER -

Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle

Abstract

All Science Journal Classification (ASJC) codes

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