TY - JOUR
T1 - Rat strain and age differences in kainic acid induced seizures
AU - Golden, Gregory T.
AU - Smith, George G.
AU - Ferraro, Thomas N.
AU - Reyes, Patricio F.
N1 - Funding Information:
We gratefullya cknowledgteh e technicaal ssis-tanceo f Felix A. Grau.T his work was supportebdy Departmenotf VeteransA ffairs Medical Research Funds.
PY - 1995/2
Y1 - 1995/2
N2 - This study reports comparative dose-response data for kainic acid (KA) induced seizures in juvenile (35-40 days old) and adult (70-90 days old) Wistar-Furth (WF), Fisher 344 (17344), Sprague-Dawley (SD) and Long-Evans Hooded (LEH) rats. Juvenile male WF (n = 51), F344 (n = 55), SD (n = 60), LEH (n = 50) and adult male WF (n = 48), F344 (n = 52), SD (n = 52), LEH (n = 53) rats were given KA 6, 8, 10, 12 or 14 mg/kg, sc. As previously demonstrated adult WF and F344 rats showed the greatest sensitivity and most reliable convulsant responses to kainic acid; SD and LEH rats were less sensitive and showed more variable convulsant responses. Regardless of strain, all juvenile rats exhibited greater sensitivity and less variable convulsant response to KA compared to adults. This was most evident in juvenile SD and LEH rats. Results suggest that while seizure sensitivity to KA decreases with age, genetic factors may regulate the expression of this resistance.
AB - This study reports comparative dose-response data for kainic acid (KA) induced seizures in juvenile (35-40 days old) and adult (70-90 days old) Wistar-Furth (WF), Fisher 344 (17344), Sprague-Dawley (SD) and Long-Evans Hooded (LEH) rats. Juvenile male WF (n = 51), F344 (n = 55), SD (n = 60), LEH (n = 50) and adult male WF (n = 48), F344 (n = 52), SD (n = 52), LEH (n = 53) rats were given KA 6, 8, 10, 12 or 14 mg/kg, sc. As previously demonstrated adult WF and F344 rats showed the greatest sensitivity and most reliable convulsant responses to kainic acid; SD and LEH rats were less sensitive and showed more variable convulsant responses. Regardless of strain, all juvenile rats exhibited greater sensitivity and less variable convulsant response to KA compared to adults. This was most evident in juvenile SD and LEH rats. Results suggest that while seizure sensitivity to KA decreases with age, genetic factors may regulate the expression of this resistance.
UR - http://www.scopus.com/inward/record.url?scp=0028869487&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028869487&partnerID=8YFLogxK
U2 - 10.1016/0920-1211(94)00079-C
DO - 10.1016/0920-1211(94)00079-C
M3 - Article
C2 - 7750511
AN - SCOPUS:0028869487
SN - 0920-1211
VL - 20
SP - 151
EP - 159
JO - Epilepsy Research
JF - Epilepsy Research
IS - 2
ER -