Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Wade H. Berrettini; Thomas N. Ferraro; Robert C. Alexander; Arthur M. Buchberg; Wolfgang H. Vogel

doi:10.1038/ng0594-54

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Wade H. Berrettini
, Thomas N. Ferraro
, Robert C. Alexander
, Arthur M. Buchberg
, Wolfgang H. Vogel

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F₂ intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.

Original language	English (US)
Pages (from-to)	54-58
Number of pages	5
Journal	Nature Genetics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/ng0594-54
State	Published - May 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1038/ng0594-54

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title = "Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains",

abstract = "Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7\%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85\% of the genetic variance observed between the two parental strains.",

author = "Berrettini, \{Wade H.\} and Ferraro, \{Thomas N.\} and Alexander, \{Robert C.\} and Buchberg, \{Arthur M.\} and Vogel, \{Wolfgang H.\}",

year = "1994",

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doi = "10.1038/ng0594-54",

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AU - Berrettini, Wade H.

AU - Ferraro, Thomas N.

AU - Alexander, Robert C.

AU - Buchberg, Arthur M.

AU - Vogel, Wolfgang H.

PY - 1994/5

Y1 - 1994/5

N2 - Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.

AB - Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.

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ER -

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Abstract

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