Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Wade H. Berrettini, Thomas N. Ferraro, Robert C. Alexander, Arthur M. Buchberg, Wolfgang H. Vogel

Research output: Contribution to journalArticle

163 Scopus citations

Abstract

Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalNature Genetics
Volume7
Issue number1
DOIs
StatePublished - May 1994

All Science Journal Classification (ASJC) codes

  • Genetics

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