Propofol inhibits SIRT2 deacetylase through a conformationspecific, allosteric site

Brian P. Weiser, Roderic G. Eckenhoff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: The general anesthetic propofol binds many on-pathway and off-pathway proteins. Results: The deacetylase SIRT2 is a target of propofol, and propofol can inhibit the enzymatic function of the protein. Conclusion: SIRT2 is a novel, presumably off-pathway protein target of the general anesthetic propofol. Significance: Propofol might affect cellular events that are regulated by the acetylation state of proteins.

Original languageEnglish (US)
Pages (from-to)8559-8568
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Propofol inhibits SIRT2 deacetylase through a conformationspecific, allosteric site'. Together they form a unique fingerprint.

Cite this