Background: The general anesthetic propofol binds many on-pathway and off-pathway proteins. Results: The deacetylase SIRT2 is a target of propofol, and propofol can inhibit the enzymatic function of the protein. Conclusion: SIRT2 is a novel, presumably off-pathway protein target of the general anesthetic propofol. Significance: Propofol might affect cellular events that are regulated by the acetylation state of proteins.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology