Prolonged 5-HTIA/5-HT2A receptor cross-talk is absent prior to adulthood in rats

Maureen L. Petrunicha, Francisca Garcia, Gonzalo A. Carrasco, George Battaglia

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In adult rats, serotonin IA (5-HTIa) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2a) neuroendocrine function at I h that persists up to 72 h. This study determined whether proloinfnged 5-HTIa/5-HT2a cross-talk exists before sexual maturation. Adolescent male rats (postnatal day 39) received an injection with saline or ( + )- 8-hydroxy-2-(di-n-propyl-amino)tetralin hydrobromide [( + )8-OH-DPAT] 24 h before receiving a challenge injection of saline, ( + )-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, or (-)-l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HCl [(-)DOI] o assess changes in basal, 5-HTIa, and 5-HT2A receptor-mediated hormone responses. Although homologous desensitization of 5-HTIA neuroendocrine responses was present at 24 h, heterologous desensitization of 5-HT2A neuroendocrine responses was not.These data suggest that 5-HTIA heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation.

Original languageEnglish (US)
Pages (from-to)1457-1461
Number of pages5
Issue number15
StatePublished - Oct 8 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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