Abstract
In adult rats, serotonin IA (5-HTIa) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2a) neuroendocrine function at I h that persists up to 72 h. This study determined whether proloinfnged 5-HTIa/5-HT2a cross-talk exists before sexual maturation. Adolescent male rats (postnatal day 39) received an injection with saline or ( + )- 8-hydroxy-2-(di-n-propyl-amino)tetralin hydrobromide [( + )8-OH-DPAT] 24 h before receiving a challenge injection of saline, ( + )-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, or (-)-l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HCl [(-)DOI] o assess changes in basal, 5-HTIa, and 5-HT2A receptor-mediated hormone responses. Although homologous desensitization of 5-HTIA neuroendocrine responses was present at 24 h, heterologous desensitization of 5-HT2A neuroendocrine responses was not.These data suggest that 5-HTIA heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1457-1461 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 19 |
| Issue number | 15 |
| DOIs | |
| State | Published - Oct 8 2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Prolonged 5-HTIA/5-HT2A receptor cross-talk is absent prior to adulthood in rats. / Petrunicha, Maureen L.; Garcia, Francisca; Carrasco, Gonzalo; Battaglia, George.
In: NeuroReport, Vol. 19, No. 15, 08.10.2008, p. 1457-1461.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prolonged 5-HTIA/5-HT2A receptor cross-talk is absent prior to adulthood in rats
AU - Petrunicha, Maureen L.
AU - Garcia, Francisca
AU - Carrasco, Gonzalo
AU - Battaglia, George
PY - 2008/10/8
Y1 - 2008/10/8
N2 - In adult rats, serotonin IA (5-HTIa) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2a) neuroendocrine function at I h that persists up to 72 h. This study determined whether proloinfnged 5-HTIa/5-HT2a cross-talk exists before sexual maturation. Adolescent male rats (postnatal day 39) received an injection with saline or ( + )- 8-hydroxy-2-(di-n-propyl-amino)tetralin hydrobromide [( + )8-OH-DPAT] 24 h before receiving a challenge injection of saline, ( + )-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, or (-)-l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HCl [(-)DOI] o assess changes in basal, 5-HTIa, and 5-HT2A receptor-mediated hormone responses. Although homologous desensitization of 5-HTIA neuroendocrine responses was present at 24 h, heterologous desensitization of 5-HT2A neuroendocrine responses was not.These data suggest that 5-HTIA heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation.
AB - In adult rats, serotonin IA (5-HTIa) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2a) neuroendocrine function at I h that persists up to 72 h. This study determined whether proloinfnged 5-HTIa/5-HT2a cross-talk exists before sexual maturation. Adolescent male rats (postnatal day 39) received an injection with saline or ( + )- 8-hydroxy-2-(di-n-propyl-amino)tetralin hydrobromide [( + )8-OH-DPAT] 24 h before receiving a challenge injection of saline, ( + )-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, or (-)-l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HCl [(-)DOI] o assess changes in basal, 5-HTIa, and 5-HT2A receptor-mediated hormone responses. Although homologous desensitization of 5-HTIA neuroendocrine responses was present at 24 h, heterologous desensitization of 5-HT2A neuroendocrine responses was not.These data suggest that 5-HTIA heterologous desensitization of 5-HT2A receptor function does not develop until adulthood, is more transient, or follows a different time course before maturation.
UR - http://www.scopus.com/inward/record.url?scp=53549116445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53549116445&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e32830edd6d
DO - 10.1097/WNR.0b013e32830edd6d
M3 - Article
C2 - 18797297
AN - SCOPUS:53549116445
VL - 19
SP - 1457
EP - 1461
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15
ER -