Progressive peripheral agraphia

M. Grossman, D. J. Libon, X. S. Ding, B. Cloud, J. Jaggi, D. Morrison, J. Greenberg, A. Alavi, M. Reivich

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We describe RW, a patient who presented with writing difficulty that deteriorated over time. While her graphemes were typically legible, her writing was extremely slow, and her letters were written in an inconsistent and heterogeneous manner (e.g. each 'a' in the word 'banana' was produced in a different way). Her mental imagery of letters was impoverished, and she also produced allographic errors in her writing. She had some spelling errors as well, but many of these were due to omissions, perseverations, and motor operations. A positron emission tomography scan demonstrated superior parietal occipital and superior frontal defects that were more evident on the left than the right. Our observations are consistent with the hypothesis that RW has a deficit retrieving physical letter forms as manifested by her heterogeneous and slow production of letter forms. This disruption of grapheme retrieval is associated with interruption of a superior frontal-parietal system in the left hemisphere.

Original languageEnglish (US)
Pages (from-to)339-349
Number of pages11
Issue number4
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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