Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

Sheryl S. Smith; Barry D. Waterhouse; John K. Chapin; Donald J. Woodward

doi:10.1016/0006-8993(87)90634-2

Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

Sheryl S. Smith
, Barry D. Waterhouse
, John K. Chapin
, Donald J. Woodward

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Abstract

In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.

Original language	English (US)
Pages (from-to)	353-359
Number of pages	7
Journal	Brain Research
Volume	400
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90634-2
State	Published - Jan 6 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90634-2

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title = "Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action",

abstract = "In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.",

author = "Smith, \{Sheryl S.\} and Waterhouse, \{Barry D.\} and Chapin, \{John K.\} and Woodward, \{Donald J.\}",

note = "Funding Information: The authors are grateful for support from MH09010 to S,S.S. and AA3901, DA01338 and a grant from the Biological Humanics Foundation to D.J.W.",

year = "1987",

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doi = "10.1016/0006-8993(87)90634-2",

language = "English (US)",

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TY - JOUR

T1 - Progesterone alters GABA and glutamate responsiveness

T2 - a possible mechanism for its anxiolytic action

AU - Smith, Sheryl S.

AU - Waterhouse, Barry D.

AU - Chapin, John K.

AU - Woodward, Donald J.

N1 - Funding Information: The authors are grateful for support from MH09010 to S,S.S. and AA3901, DA01338 and a grant from the Biological Humanics Foundation to D.J.W.

PY - 1987/1/6

Y1 - 1987/1/6

N2 - In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.

AB - In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.

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JO - Brain Research

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ER -

Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

Abstract

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