TY - JOUR
T1 - Progesterone alters GABA and glutamate responsiveness
T2 - a possible mechanism for its anxiolytic action
AU - Smith, Sheryl S.
AU - Waterhouse, Barry D.
AU - Chapin, John K.
AU - Woodward, Donald J.
N1 - Funding Information:
The authors are grateful for support from MH09010 to S,S.S. and AA3901, DA01338 and a grant from the Biological Humanics Foundation to D.J.W.
PY - 1987/1/6
Y1 - 1987/1/6
N2 - In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.
AB - In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied γ-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.
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U2 - 10.1016/0006-8993(87)90634-2
DO - 10.1016/0006-8993(87)90634-2
M3 - Article
C2 - 2880640
AN - SCOPUS:0023271933
SN - 0006-8993
VL - 400
SP - 353
EP - 359
JO - Brain Research
JF - Brain Research
IS - 2
ER -