TY - JOUR
T1 - Preparative-scale synthesis of both antipodes of B-γ,γ- dimethylallyldiisopinocampheylborane
T2 - Application for the synthesis of C 1-C6 subunit of epothilone
AU - Ramachandran, P. Veeraraghavan
AU - Prabhudas, Bodhuri
AU - Chandra, J. Subash
AU - Reddy, M. Venkat Ram
AU - Brown, Herbert C.
PY - 2004/1/26
Y1 - 2004/1/26
N2 - A preparative-scale synthesis of B-γ,γ- dimethylallyldiisopinocampheylborane starting from prenyl alcohol has been described. This reagent, upon reaction with various aldehydes, provides the corresponding α,α-dimethylhomoallylic alcohols in high enantioselectivities. The application of this reagent has been demonstrated for the synthesis of C1-C6 subunit of epothilone.
AB - A preparative-scale synthesis of B-γ,γ- dimethylallyldiisopinocampheylborane starting from prenyl alcohol has been described. This reagent, upon reaction with various aldehydes, provides the corresponding α,α-dimethylhomoallylic alcohols in high enantioselectivities. The application of this reagent has been demonstrated for the synthesis of C1-C6 subunit of epothilone.
UR - http://www.scopus.com/inward/record.url?scp=0347022324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347022324&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2003.11.087
DO - 10.1016/j.tetlet.2003.11.087
M3 - Article
AN - SCOPUS:0347022324
SN - 0040-4039
VL - 45
SP - 1011
EP - 1013
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 5
ER -