TY - JOUR
T1 - Pregnancy and Cancer
T2 - the INCIP Project
AU - for the International Network on Cancer, Infertility and Pregnancy (INCIP)
AU - Maggen, Charlotte
AU - Wolters, Vera E.R.A.
AU - Cardonick, Elyce
AU - Fumagalli, Monica
AU - Halaska, Michael J.
AU - Lok, Christianne A.R.
AU - de Haan, Jorine
AU - Van Tornout, Katrien
AU - Van Calsteren, Kristel
AU - Amant, Frédéric
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Purpose of Review: Cancer diagnosis in young pregnant women challenges oncological decision-making. The International Network on Cancer, Infertility and Pregnancy (INCIP) aims to build on clinical recommendations based on worldwide collaborative research. Recent Findings: A pregnancy may complicate diagnostic and therapeutic oncological options, as the unborn child must be protected from potentially hazardous exposures. Pregnant patients should as much as possible be treated as non-pregnant patients, in order to preserve maternal prognosis. Some approaches need adaptations when compared with standard treatment for fetal reasons. Depending on the gestational age, surgery, radiotherapy, and chemotherapy are possible during pregnancy. A multidisciplinary approach is the best guarantee for experience-driven decisions. A setting with a high-risk obstetrical unit is strongly advised to safeguard fetal growth and health. Research wise, the INCIP invests in clinical follow-up of children, as cardiac function, neurodevelopment, cancer occurrence, and fertility theoretically may be affected. Furthermore, parental psychological coping strategies, (epi)genetic alterations, and pathophysiological placental changes secondary to cancer (treatment) are topics of ongoing research. Summary: Further international research is needed to provide patients diagnosed with cancer during pregnancy with the best individualized management plan to optimize obstetrical and oncological care.
AB - Purpose of Review: Cancer diagnosis in young pregnant women challenges oncological decision-making. The International Network on Cancer, Infertility and Pregnancy (INCIP) aims to build on clinical recommendations based on worldwide collaborative research. Recent Findings: A pregnancy may complicate diagnostic and therapeutic oncological options, as the unborn child must be protected from potentially hazardous exposures. Pregnant patients should as much as possible be treated as non-pregnant patients, in order to preserve maternal prognosis. Some approaches need adaptations when compared with standard treatment for fetal reasons. Depending on the gestational age, surgery, radiotherapy, and chemotherapy are possible during pregnancy. A multidisciplinary approach is the best guarantee for experience-driven decisions. A setting with a high-risk obstetrical unit is strongly advised to safeguard fetal growth and health. Research wise, the INCIP invests in clinical follow-up of children, as cardiac function, neurodevelopment, cancer occurrence, and fertility theoretically may be affected. Furthermore, parental psychological coping strategies, (epi)genetic alterations, and pathophysiological placental changes secondary to cancer (treatment) are topics of ongoing research. Summary: Further international research is needed to provide patients diagnosed with cancer during pregnancy with the best individualized management plan to optimize obstetrical and oncological care.
UR - https://www.scopus.com/pages/publications/85079037607
UR - https://www.scopus.com/inward/citedby.url?scp=85079037607&partnerID=8YFLogxK
U2 - 10.1007/s11912-020-0862-7
DO - 10.1007/s11912-020-0862-7
M3 - Review article
C2 - 32025953
AN - SCOPUS:85079037607
SN - 1523-3790
VL - 22
JO - Current Oncology Reports
JF - Current Oncology Reports
IS - 2
M1 - 17
ER -