TY - JOUR
T1 - Prednisone Effects on Neurochemistry and Behavior
T2 - Preliminary Findings
AU - Wolkowitz, Owen M.
AU - Rubinow, David
AU - Doran, Allen R.
AU - Breier, Alan
AU - Berrettini, Wade H.
AU - Kling, Mitchel A.
AU - Pickar, David
PY - 1990/10
Y1 - 1990/10
N2 - To evaluate the neurochemical, neuroendocrine, and behavioral effects of exogenous corticosteroids in humans, we administered prednisone (80 mg/d orally for 5 days) in a double-blind manner to 12 medically healthy volunteers. Behavioral measures were assessed before, during, and after prednisone administration in all 12 subjects, and cerebrospinal fluid biochemistry was assessed before and during prednisone administration in 9 of the subjects. Prednisone administration was associated with decreases in cerebrospinal fluid levels of corticotropin, norepinephrine, β-endorphin, β-lipotropin, and somatostatinlike immunoreactivity. No significant changes were noted in cerebrospinal fluid levels of α-melanocyte-stimulating hormone, corticotropinreleasing hormone, 3-methoxy-4-hydroxyphenylglycol, homevanillic acid, or 5-hydroxyindoleacetic acid. No consistent or significant group mean changes were observed in structured behavioral ratings, although 9 (75%) of the volunteers studied reported mild behavioral changes while receiving prednisone. Correlations between the neurochemical and behavioral changes are discussed.
AB - To evaluate the neurochemical, neuroendocrine, and behavioral effects of exogenous corticosteroids in humans, we administered prednisone (80 mg/d orally for 5 days) in a double-blind manner to 12 medically healthy volunteers. Behavioral measures were assessed before, during, and after prednisone administration in all 12 subjects, and cerebrospinal fluid biochemistry was assessed before and during prednisone administration in 9 of the subjects. Prednisone administration was associated with decreases in cerebrospinal fluid levels of corticotropin, norepinephrine, β-endorphin, β-lipotropin, and somatostatinlike immunoreactivity. No significant changes were noted in cerebrospinal fluid levels of α-melanocyte-stimulating hormone, corticotropinreleasing hormone, 3-methoxy-4-hydroxyphenylglycol, homevanillic acid, or 5-hydroxyindoleacetic acid. No consistent or significant group mean changes were observed in structured behavioral ratings, although 9 (75%) of the volunteers studied reported mild behavioral changes while receiving prednisone. Correlations between the neurochemical and behavioral changes are discussed.
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U2 - 10.1001/archpsyc.1990.01810220079010
DO - 10.1001/archpsyc.1990.01810220079010
M3 - Article
C2 - 1977371
AN - SCOPUS:0025168915
SN - 0003-990X
VL - 47
SP - 963
EP - 968
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 10
ER -