Predictive models of cognitive outcomes of developmental insults

Yupo Chan, Nidhal Bouaynaya, Parimal Chowdhury, Danuta Leszczynska, Tucker A. Patterson, Olga Tarasenko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Representatives of Arkansas medical, research and educational institutions have gathered over the past four years to discuss the relationship between functional developmental perturbations and their neurological consequences. We wish to track the effect on the nervous system by developmental perturbations over time and across species. Except for perturbations, the sequence of events that occur during neural development was found to be remarkably conserved across mammalian species. The tracking includes consequences on anatomical regions and behavioral changes. The ultimate goal is to develop a predictive model of long-term genotypic and phenotypic outcomes that includes developmental insults. Such a model can subsequently be fostered into an educated intervention for therapeutic purposes. Several datasets were identified to test plausible hypotheses, ranging from evoked potential datasets to sleep-disorder datasets. An initial model may be mathematical and conceptual. However, we expect to see rapid progress as large-scale gene expression studies in the mammalian brain permit genome-wide searches to discover genes that are uniquely expressed in brain circuits and regions. These genes ultimately control behavior. By using a validated model we endeavor to make useful predictions.

Original languageEnglish (US)
Title of host publicationBiology, Nanotechnology, Toxicology, and Applications - Proceedings of the 4th BioNanoTox and Applications Research Conference
Pages87-93
Number of pages7
DOIs
StatePublished - Jun 14 2010
Externally publishedYes
Event4th BioNanoTox (Biology, Nanotechnology, and Toxicology) and Applications Research Conference - Little Rock, AR, United States
Duration: Oct 21 2009Oct 22 2009

Publication series

NameAIP Conference Proceedings
Volume1229
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other4th BioNanoTox (Biology, Nanotechnology, and Toxicology) and Applications Research Conference
Country/TerritoryUnited States
CityLittle Rock, AR
Period10/21/0910/22/09

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • Physics and Astronomy(all)
  • Nature and Landscape Conservation

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