TY - GEN
T1 - Predictive models of cognitive outcomes of developmental insults
AU - Chan, Yupo
AU - Bouaynaya, Nidhal
AU - Chowdhury, Parimal
AU - Leszczynska, Danuta
AU - Patterson, Tucker A.
AU - Tarasenko, Olga
PY - 2010
Y1 - 2010
N2 - Representatives of Arkansas medical, research and educational institutions have gathered over the past four years to discuss the relationship between functional developmental perturbations and their neurological consequences. We wish to track the effect on the nervous system by developmental perturbations over time and across species. Except for perturbations, the sequence of events that occur during neural development was found to be remarkably conserved across mammalian species. The tracking includes consequences on anatomical regions and behavioral changes. The ultimate goal is to develop a predictive model of long-term genotypic and phenotypic outcomes that includes developmental insults. Such a model can subsequently be fostered into an educated intervention for therapeutic purposes. Several datasets were identified to test plausible hypotheses, ranging from evoked potential datasets to sleep-disorder datasets. An initial model may be mathematical and conceptual. However, we expect to see rapid progress as large-scale gene expression studies in the mammalian brain permit genome-wide searches to discover genes that are uniquely expressed in brain circuits and regions. These genes ultimately control behavior. By using a validated model we endeavor to make useful predictions.
AB - Representatives of Arkansas medical, research and educational institutions have gathered over the past four years to discuss the relationship between functional developmental perturbations and their neurological consequences. We wish to track the effect on the nervous system by developmental perturbations over time and across species. Except for perturbations, the sequence of events that occur during neural development was found to be remarkably conserved across mammalian species. The tracking includes consequences on anatomical regions and behavioral changes. The ultimate goal is to develop a predictive model of long-term genotypic and phenotypic outcomes that includes developmental insults. Such a model can subsequently be fostered into an educated intervention for therapeutic purposes. Several datasets were identified to test plausible hypotheses, ranging from evoked potential datasets to sleep-disorder datasets. An initial model may be mathematical and conceptual. However, we expect to see rapid progress as large-scale gene expression studies in the mammalian brain permit genome-wide searches to discover genes that are uniquely expressed in brain circuits and regions. These genes ultimately control behavior. By using a validated model we endeavor to make useful predictions.
UR - http://www.scopus.com/inward/record.url?scp=77953261952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953261952&partnerID=8YFLogxK
U2 - 10.1063/1.3419706
DO - 10.1063/1.3419706
M3 - Conference contribution
AN - SCOPUS:77953261952
SN - 9780735407732
T3 - AIP Conference Proceedings
SP - 87
EP - 93
BT - Biology, Nanotechnology, Toxicology, and Applications - Proceedings of the 4th BioNanoTox and Applications Research Conference
T2 - 4th BioNanoTox (Biology, Nanotechnology, and Toxicology) and Applications Research Conference
Y2 - 21 October 2009 through 22 October 2009
ER -