Potent irreversible inhibitors of LasR quorum sensing in Pseudomonas aeruginosa

Kevin T. O'Brien, Joseph G. Noto, Luke Nichols-O'Neill, Lark J. Perez

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalACS Medicinal Chemistry Letters
Volume6
Issue number2
DOIs
StatePublished - Feb 12 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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