Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis

Samuel W. Foster, Xiaofeng Xie, Michelle Pham, Paul A. Peaden, Leena M. Patil, Luke T. Tolley, Paul B. Farnsworth, H. Dennis Tolley, Milton L. Lee, James P. Grinias

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high-pressure syringe pumps capable of delivering capillary-scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub-2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high-pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over-the-counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six targeted drug panels. The results described in this study demonstrate the capability of this compact liquid chromatography instrument to address several important drug-related applications while simplifying system operation, and greatly reducing solvent usage and waste generation essential for onsite analysis.

Original languageEnglish (US)
Pages (from-to)1623-1627
Number of pages5
JournalJournal of Separation Science
Issue number9-10
StatePublished - May 1 2020

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Filtration and Separation


Dive into the research topics of 'Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis'. Together they form a unique fingerprint.

Cite this