Poly(ethylene imine)s as antimicrobial agents with selective activity

Katherine A. Gibney; Iva Sovadinova; Analette I. Lopez; Michael Urban; Zachary Ridgway; Gregory A. Caputo; Kenichi Kuroda

doi:10.1002/mabi.201200052

Poly(ethylene imine)s as antimicrobial agents with selective activity

Katherine A. Gibney, Iva Sovadinova, Analette I. Lopez, Michael Urban, Zachary Ridgway, Gregory A. Caputo, Kenichi Kuroda

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141 Scopus citations

Abstract

We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity.

Original language	English (US)
Pages (from-to)	1279-1289
Number of pages	11
Journal	Macromolecular Bioscience
Volume	12
Issue number	9
DOIs	https://doi.org/10.1002/mabi.201200052
State	Published - Sep 2012

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.201200052

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title = "Poly(ethylene imine)s as antimicrobial agents with selective activity",

abstract = "We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity.",

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AU - Gibney, Katherine A.

AU - Sovadinova, Iva

AU - Lopez, Analette I.

AU - Urban, Michael

AU - Ridgway, Zachary

AU - Caputo, Gregory A.

AU - Kuroda, Kenichi

PY - 2012/9

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Poly(ethylene imine)s as antimicrobial agents with selective activity

Abstract

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