Pervaporation as a green drying process for tetrahydrofuran recovery in pharmaceutical synthesis

C. Stewart Slater, Mariano J. Savelski, Timothy M. Moroz, Michael J. Raymond

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The use of pervaporation technology as a green drying process for the recovery and reuse of the solvent, tetrahyrdofuran, in a pharmaceutical synthesis has been evaluated. A case study has been performed on a step in the synthesis of a new oncology drug. Pervaporation has been integrated with a constant-volume distillation process to produce a hybrid system that allows for the recovery and reuse of tetrahydrofuran. An economic and environmental analysis shows that this is an effective technology for this application.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalGreen Chemistry Letters and Reviews
Volume5
Issue number1
DOIs
StatePublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry

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