Peptide probes for protein transmembrane domains

Peter F. Slivka, Johnny Wong, Gregory A. Caputo, Hang Yin

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Much current interest in chemical biology focuses on the transmembrane domains of proteins, which have emerged as targets for the development of novel diagnostics and therapeutics. Integral membrane proteins are a group of important biomolecules that play pivotal roles in many cellular activities. Previous studies primarily focused on the extra- and/or intracellular domains of membrane proteins. However, the importance of transmembrane regions in the regulation of protein complexes is beginning to emerge. As such, a number of methods for designing and testing novel exogenous peptides that recognize transmembrane targets and modulate cellular functions have been developed. This Review outlines current methodologies for developing these transmembrane probes that may provide useful tools to study a variety of biological phenomena in the membrane.

Original languageEnglish (US)
Pages (from-to)402-411
Number of pages10
JournalACS Chemical Biology
Issue number7
StatePublished - Jul 18 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine


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