Pathways to therapy resistance: The sheltering effect of the bone marrow microenvironment to multiple myeloma cells

Kuntal Bhowmick, Max von Suskil, Omar S. Al-Odat, Weam Othman Elbezanti, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj Pandey

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple Myeloma (MM) is a malignant expansion of plasma cells in the bone marrow (BM), resulting in a disease characterized by symptoms of end organ damage from light chain secretion, crowding of the BM, and bone lesions. Although the past two decades have been characterized by numerous novel therapies emerging, the disease remains incurable due to intrinsic or acquired drug resistance. A major player in MM's drug resistance arises from its intimate relationship with the BM microenvironment (BMME). Through stress-inducing conditions, soluble messengers, and physical adhesion to BM elements, the BMME activates numerous pathways in the myeloma cell. This not only propagates myeloma progression through survival and growth signals, but also specific mechanisms to circumvent therapeutic actions. In this review, we provide an overview of the BMME, the role of individual components in MM survival, and various therapy-specific resistance mechanisms reported in the literature.

Original languageEnglish (US)
Article numbere33091
JournalHeliyon
Volume10
Issue number12
DOIs
StatePublished - Jun 30 2024

All Science Journal Classification (ASJC) codes

  • General

Fingerprint

Dive into the research topics of 'Pathways to therapy resistance: The sheltering effect of the bone marrow microenvironment to multiple myeloma cells'. Together they form a unique fingerprint.

Cite this