TY - JOUR
T1 - Oxidative stress early in pregnancy and pregnancy outcome
AU - Stein, T. Peter
AU - Scholl, Theresa O.
AU - Schluter, Margaret D.
AU - Leskiw, Maria J.
AU - Chen, Xinhua
AU - Spur, Bernd W.
AU - Rodriguez, Ana
PY - 2008/11/17
Y1 - 2008/11/17
N2 - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.
AB - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.
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U2 - 10.1080/10715760802510069
DO - 10.1080/10715760802510069
M3 - Article
C2 - 18985484
AN - SCOPUS:55849149026
VL - 42
SP - 841
EP - 848
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 10
ER -