Oxidative stress early in pregnancy and pregnancy outcome

T. Peter Stein; Theresa O. Scholl; Margaret D. Schluter; Maria J. Leskiw; Xinhua Chen; Bernd W. Spur; Ana Rodriguez

doi:10.1080/10715760802510069

Oxidative stress early in pregnancy and pregnancy outcome

T. Peter Stein, Theresa O. Scholl, Margaret D. Schluter, Maria J. Leskiw, Xinhua Chen, Bernd W. Spur, Ana Rodriguez

Cell Biology

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF_2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

Original language	English (US)
Pages (from-to)	841-848
Number of pages	8
Journal	Free Radical Research
Volume	42
Issue number	10
DOIs	https://doi.org/10.1080/10715760802510069
State	Published - 2008

All Science Journal Classification (ASJC) codes

Biochemistry

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10.1080/10715760802510069

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title = "Oxidative stress early in pregnancy and pregnancy outcome",

abstract = "The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.",

author = "Stein, {T. Peter} and Scholl, {Theresa O.} and Schluter, {Margaret D.} and Leskiw, {Maria J.} and Xinhua Chen and Spur, {Bernd W.} and Ana Rodriguez",

note = "Funding Information: This work was supported by a grant from the National Institute of Child Health and Human Development, HD38329). We thank the staff of the Osborn Family Health Center, Our Lady of Lourdes Hospital for providing access to patients.",

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T1 - Oxidative stress early in pregnancy and pregnancy outcome

AU - Stein, T. Peter

AU - Scholl, Theresa O.

AU - Schluter, Margaret D.

AU - Leskiw, Maria J.

AU - Chen, Xinhua

AU - Spur, Bernd W.

AU - Rodriguez, Ana

N1 - Funding Information: This work was supported by a grant from the National Institute of Child Health and Human Development, HD38329). We thank the staff of the Osborn Family Health Center, Our Lady of Lourdes Hospital for providing access to patients.

PY - 2008

Y1 - 2008

N2 - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

AB - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

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Oxidative stress early in pregnancy and pregnancy outcome

Abstract

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