Oxidative stress early in pregnancy and pregnancy outcome

T. Peter Stein, Theresa O. Scholl, Margaret D. Schluter, Maria J. Leskiw, Xinhua Chen, Bernd W. Spur, Ana Rodriguez

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

Original languageEnglish (US)
Pages (from-to)841-848
Number of pages8
JournalFree Radical Research
Volume42
Issue number10
DOIs
StatePublished - Nov 17 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry

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