Oxidative stress early in pregnancy and pregnancy outcome

T. Peter Stein; Theresa O. Scholl; Margaret D. Schluter; Maria J. Leskiw; Xinhua Chen; Bernd W. Spur; Ana Rodriguez

doi:10.1080/10715760802510069

Oxidative stress early in pregnancy and pregnancy outcome

T. Peter Stein, Theresa O. Scholl, Margaret D. Schluter, Maria J. Leskiw, Xinhua Chen, Bernd W. Spur, Ana Rodriguez

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF_2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

Original language	English (US)
Pages (from-to)	841-848
Number of pages	8
Journal	Free Radical Research
Volume	42
Issue number	10
DOIs	https://doi.org/10.1080/10715760802510069
State	Published - Nov 17 2008

All Science Journal Classification (ASJC) codes

Biochemistry

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abstract = "The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.",

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AU - Stein, T. Peter

AU - Scholl, Theresa O.

AU - Schluter, Margaret D.

AU - Leskiw, Maria J.

AU - Chen, Xinhua

AU - Spur, Bernd W.

AU - Rodriguez, Ana

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AB - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

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