Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid

Jeremy S. Francis, Michael Dragunow, Matthew J. During

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

ATF-3 is a member of the ATF superfamily of transcription factors and is strongly associated with episodes of cellular stress. We demonstrate an association between increases in ATF-3 protein and resistance to exitotoxic cell death in vivo. Intra-hippocampal injection of kainic acid elicited a robust increase in endogenous ATF-3 within kainate-resistant cells of the dentate gyrus, while overexpression of exogenous ATF-3 was found to protect vulnerable CA3 neurons from the same insult. These results suggest a positive contribution to neuronal survival in the context of stress-induced death, and support an anti-apoptotic role for ATF-3 in the brain.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalMolecular Brain Research
Volume124
Issue number2
DOIs
StatePublished - May 19 2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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