Opioid-induced endocrinopathy

Stephen Colameco, Joshua S. Coren

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Debilitating chronic nonmalignant pain is often managed using opioid medications. However, with increased use of this drug class comes concern about adverse effects on patients' endocrine function. In the present review, the authors discuss opioid-induced interference with the hypothalamic-pituitary- gonadal axis, effects on adrenal androgen production, and endocrine deficiency. In addition, the authors describe symptomology for opioid-induced endocrinopathy as well as diagnostic testing options. Treatment modalities for those afflicted with this condition are also described.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalJournal of the American Osteopathic Association
Issue number1
StatePublished - Jan 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine


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