TY - JOUR
T1 - Old drugs, new uses
T2 - Drug repurposing in hematological malignancies
AU - Kale, Vijay P.
AU - Habib, Hasan
AU - Chitren, Robert
AU - Patel, Milan
AU - Pramanik, Kartick C.
AU - Jonnalagadda, Subash C.
AU - Challagundla, Kishore
AU - Pandey, Manoj K.
N1 - Funding Information:
This work was supported by funds from Cooper Medical School of Rowan University, Camden, NJ (M.K.P.), New Jersey Health Foundation (S.C.J. and M.K.P.), and Camden Health Research Initiative grant (M.K.P, and S.C.J.).
Publisher Copyright:
© 2020
PY - 2021/1
Y1 - 2021/1
N2 - Discovery and development of novel anti-cancer drugs are expensive and time consuming. Systems biology approaches have revealed that a drug being developed for a non-cancer indication can hit other targets as well, which play critical roles in cancer progression. Since drugs for non-cancer indications would have already gone through the preclinical and partial or full clinical development, repurposing such drugs for hematological malignancies would cost much less, and drastically reduce the development time, which is evident in case of thalidomide. Here, we have reviewed some of the drugs for their potential to repurpose for treating the hematological malignancies. We have also enlisted resources that can be helpful in drug repurposing.
AB - Discovery and development of novel anti-cancer drugs are expensive and time consuming. Systems biology approaches have revealed that a drug being developed for a non-cancer indication can hit other targets as well, which play critical roles in cancer progression. Since drugs for non-cancer indications would have already gone through the preclinical and partial or full clinical development, repurposing such drugs for hematological malignancies would cost much less, and drastically reduce the development time, which is evident in case of thalidomide. Here, we have reviewed some of the drugs for their potential to repurpose for treating the hematological malignancies. We have also enlisted resources that can be helpful in drug repurposing.
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U2 - 10.1016/j.semcancer.2020.03.005
DO - 10.1016/j.semcancer.2020.03.005
M3 - Review article
C2 - 32151704
AN - SCOPUS:85081557108
VL - 68
SP - 242
EP - 248
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
ER -