Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis

J. L. Macpherson, A. Kemp, M. Rogers, A. I. Mallet, R. F. Toia, B. Spur, J. W. Earl, C. N. Chesterman, S. A. Krilis

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We have identified PAF in the blister fluid from a patient with bullous mastocytosis, a rare form of mast-cell disease. We have found a novel endogenous inhibitor of platelet aggregation which obscured the presence of the PAF in unprocessed blister fluid and in ethanol or lipid extracts. The PAF was characterized by the demonstration of chromatographic, mass spectral and biological properties identical to those of authentic PAF. Thus this is the first demonstration of PAF in biological fluid from a patient with mastocytosis. High levels of immunoreactive prostaglandin D2 (PGD2) and histamine were also present in the blister fluid. The interaction between PAF and the inhibitor of platelet aggregation in patients with systemic mastocytosis may provide and explanation for some of the manifestations of the disease, in particular the episodic hypotension, cutaneous flushing and pallor.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalClinical and Experimental Immunology
Volume77
Issue number3
StatePublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis'. Together they form a unique fingerprint.

Cite this