Observation of enhanced heat dissipation in columns packed with superficially porous particles

James P. Grinias, Dayley S. Keil, James W. Jorgenson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

At high flow rates and pressures, columns packed with sub-2. μm particles suffer from efficiency losses due to frictional heating. The thermal environment of the column (insulated or isothermal) can decrease or magnify these losses. While a number of studies have been conducted demonstrating the improved performance (partially due to the benefits of enhanced thermal conductivity) of columns packed with superficially porous particles, none have made a comparison between sub-2. μm fully and superficially porous particles in an isothermal environment where radial thermal gradients are maximized and thermal broadening is amplified. Here we show that when such columns are characterized in a recirculating water jacket (providing an isothermal environment), efficiency loss and changes in retention and mobile phase temperature are reduced for sub-2. μm superficially porous particles compared to sub-2. μm fully porous particles.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalJournal of Chromatography A
Volume1371
DOIs
StatePublished - Dec 5 2014

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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