Nuclear magnetic resonance spectroscopy | Hyperpolarization for sensitivity enhancement

Boyd M. Goodson, Bryce Kidd, Jan Bernd Hövener, Leif Schröder, Thomas Theis, Nicholas Whiting, Eduard Y. Chekmenev

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Nuclear spin polarization can be significantly enhanced through a process called hyperpolarization, resulting in up to several orders increase of the nuclear spin polarization (compared to equilibrium thermal polarization) with concomitant gains in NMR spectroscopic and imaging signals. Here, we describe the leading techniques for NMR hyperpolarization: dynamic nuclear polarization (DNP), spin exchange optical pumping (SEOP), parahydrogen induced polarization (PHIP), and signal amplification by reversible exchange (SABRE). We also discuss key features of and schemes associated with NMR spectroscopic detection in the context of NMR hyperpolarization applications.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Analytical Science
Number of pages14
ISBN (Electronic)9780081019832
ISBN (Print)9780081019849
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • General Chemistry


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