Novel methodologies for the synthesis of functionalized pyroglutamates

Srinivas Tekkam, M. A. Alam, Subash C. Jonnalagadda, Venkatram R. Mereddy

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations


    Alkylation of amino-acid derived iminoesters with Baylis-Hillman (BH) template based allyl bromides furnished α-methylene-β-substituted-pyroglutamates, while the corresponding alkylation with BH derived allylic acetates provided α-alkylidene-pyroglutamates. These methodologies have been applied in the synthesis of fused [3.2.0]-γ-lactam-β-lactones.

    Original languageEnglish (US)
    Pages (from-to)3219-3221
    Number of pages3
    JournalChemical Communications
    Issue number11
    StatePublished - Mar 1 2011

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry


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