Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.
|Original language||English (US)|
|Number of pages||5|
|Journal||Green Chemistry Letters and Reviews|
|State||Published - Jan 2 2016|
All Science Journal Classification (ASJC) codes
- Environmental Chemistry