Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

William C. Neuhaus; Ian J. Bakanas; Joseph R. Lizza; Charles T. Boon; Gustavo Moura-Letts

doi:10.1080/17518253.2016.1149231

Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon, Gustavo Moura-Letts

Chemistry

Research output: Contribution to journal › Letter › peer-review

23 Scopus citations

Abstract

Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

Original language	English (US)
Pages (from-to)	39-43
Number of pages	5
Journal	Green Chemistry Letters and Reviews
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/17518253.2016.1149231
State	Published - Jan 2 2016

All Science Journal Classification (ASJC) codes

General Chemistry
Environmental Chemistry

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10.1080/17518253.2016.1149231

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abstract = "Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.",

author = "Neuhaus, {William C.} and Bakanas, {Ian J.} and Lizza, {Joseph R.} and Boon, {Charles T.} and Gustavo Moura-Letts",

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AU - Neuhaus, William C.

AU - Bakanas, Ian J.

AU - Lizza, Joseph R.

AU - Boon, Charles T.

AU - Moura-Letts, Gustavo

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

AB - Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

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Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

Abstract

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