Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon, Gustavo Moura-Letts

    Research output: Contribution to journalLetterpeer-review

    16 Scopus citations

    Abstract

    Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

    Original languageEnglish (US)
    Pages (from-to)39-43
    Number of pages5
    JournalGreen Chemistry Letters and Reviews
    Volume9
    Issue number1
    DOIs
    StatePublished - Jan 2 2016

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Environmental Chemistry

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