Norepinephrine in the Cerebellum

Research output: Chapter in Book/Report/Conference proceedingChapter


Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality-specific information. As a result of these cellular actions, the noradrenergic system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 50 years. This chapter summarizes those studies and the development of this concept. Implications for developmental disorders and pathological conditions involving the cerebellum are also discussed.

Original languageEnglish (US)
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders
Subtitle of host publicationA Primer For Graduate Students, Second Edition
PublisherSpringer International Publishing
Number of pages8
ISBN (Electronic)9783031150708
ISBN (Print)9783031150692
StatePublished - Jan 1 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience


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