Norepinephrine and Synaptic Transmission in the Cerebellum

Daniel J. Chandler, Shevon E. Nicholson, Gerard Zitnik, Barry D. Waterhouse

Research output: Chapter in Book/Report/Conference proceedingChapter


Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specific information. As a result of these cellular actions, the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

Original languageEnglish (US)
Title of host publicationHandbook of the Cerebellum and Cerebellar Disorders
Subtitle of host publicationSecond Edition: Volume 3
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783030238100
ISBN (Print)9783030238094
StatePublished - Jan 1 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience


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