Norepinephrine and synaptic transmission in the cerebellum

Daniel J. Chandler; Shevon E. Nicholson; Gerard Zitnik; Barry D. Waterhouse

doi:10.1007/978-94-007-1333-8_37

Norepinephrine and synaptic transmission in the cerebellum

Daniel J. Chandler, Shevon E. Nicholson, Gerard Zitnik, Barry D. Waterhouse

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specific information. As a result of these cellular actions, the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

Original language	English (US)
Title of host publication	Handbook of the Cerebellum and Cerebellar Disorders
Publisher	Springer Netherlands
Pages	895-914
Number of pages	20
ISBN (Electronic)	9789400713338
ISBN (Print)	9789400713321
DOIs	https://doi.org/10.1007/978-94-007-1333-8_37
State	Published - Jan 1 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine
General Neuroscience

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10.1007/978-94-007-1333-8_37

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AB - Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specific information. As a result of these cellular actions, the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

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Norepinephrine and synaptic transmission in the cerebellum

Abstract

All Science Journal Classification (ASJC) codes

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