Norepinephrine and synaptic transmission in the cerebellum

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

Original languageEnglish (US)
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders
Subtitle of host publicationA Primer for Graduate Students
PublisherSpringer International Publishing
Pages237-241
Number of pages5
ISBN (Electronic)9783319245515
ISBN (Print)9783319245492
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

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