Norepinephrine and synaptic transmission in the cerebellum

Gerard Zitnik; Daniel J. Chandler; Barry D. Waterhouse

doi:10.1007/978-3-319-24551-5_30

Norepinephrine and synaptic transmission in the cerebellum

Gerard Zitnik, Daniel J. Chandler, Barry D. Waterhouse

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

Original language	English (US)
Title of host publication	Essentials of Cerebellum and Cerebellar Disorders
Subtitle of host publication	A Primer for Graduate Students
Publisher	Springer International Publishing
Pages	237-241
Number of pages	5
ISBN (Electronic)	9783319245515
ISBN (Print)	9783319245492
DOIs	https://doi.org/10.1007/978-3-319-24551-5_30
State	Published - Jan 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine
General Biochemistry, Genetics and Molecular Biology
General Neuroscience
General Agricultural and Biological Sciences

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10.1007/978-3-319-24551-5_30

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abstract = "Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.",

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AU - Chandler, Daniel J.

AU - Waterhouse, Barry D.

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N2 - Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

AB - Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specifi c information. As a result of these cellular actions the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and refl ex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.

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BT - Essentials of Cerebellum and Cerebellar Disorders

PB - Springer International Publishing

ER -

Norepinephrine and synaptic transmission in the cerebellum

Abstract

All Science Journal Classification (ASJC) codes

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