Nicotineandapos;s enhancing effects on responding maintained by conditioned reinforcers are reduced by pretreatment with mecamylamine, but not hexamethonium, in rats

Jeb Jones, Bethany R. Raiff, Jesse Dallery

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Several studies have indicated that nicotine increases responding maintained by conditioned reinforcers. We assessed the effects of subcutaneous injections of 0.3 mg/kg nicotine and two nicotinic antagonists on responding maintained by conditioned and primary reinforcers and responding during extinction in 8 Long Evans rats. Mecamylamine, a central and peripheral nicotinic antagonist, and hexamethonium, a peripheral nicotinic antagonist, were administered prior to a subset of the experimental sessions. Nicotine selectively increased responding maintained by conditioned reinforcers and mecamylamine, but not hexamethonium, attenuated this effect. These results suggest that nicotineandapos;s enhancing effect on responding maintained by conditioned reinforcers is mediated in the central nervous system.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalExperimental and Clinical Psychopharmacology
Volume18
Issue number4
DOIs
StatePublished - Aug 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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