TY - JOUR
T1 - Nanoscale viscoelasticity of extracellular matrix proteins in soft tissues
T2 - A multiscale approach
AU - Miri, Amir K.
AU - Heris, Hossein K.
AU - Mongeau, Luc
AU - Javid, Farhad
N1 - Funding Information:
This work was supported by National Institute of Health , Grant R01-DC005788 (Principal Investigator: Luc Mongeau). The authors thank Prof. François Barthelat (Department of Mechanical Engineering, McGill University) for sharing his atomic force microscope. The first author specially thanks Mr. Hadi T. Nia (Department of Mechanical Engineering, Massachusetts Institute of Technology) for his valuable comments.
PY - 2014/2
Y1 - 2014/2
N2 - It is hypothesized that the bulk viscoelasticity of soft tissues is determined by two length-scale-dependent mechanisms: the time-dependent response of the extracellular matrix (ECM) proteins at the nanometer scale and the biophysical interactions between the ECM solid structure and interstitial fluid at the micrometer scale. The latter is governed by poroelasticity theory assuming free motion of the interstitial fluid within the porous ECM structure. In a recent study (Heris, H.K., Miri, A.K., Tripathy, U., Barthelat, F., Mongeau, L., 2013. J. Mech. Behav. Biomed. Mater.), atomic force microscopy was used to measure the response of porcine vocal folds to a creep loading and a 50-nm sinusoidal oscillation. A constitutive model was calibrated and verified using a finite element model to accurately predict the nanoscale viscoelastic moduli of ECM. A generally good correlation was obtained between the predicted variation of the viscoelastic moduli with depth and that of hyaluronic acids in vocal fold tissue. We conclude that hyaluronic acids may regulate vocal fold viscoelasticity. The proposed methodology offers a characterization tool for biomaterials used in vocal fold augmentations.
AB - It is hypothesized that the bulk viscoelasticity of soft tissues is determined by two length-scale-dependent mechanisms: the time-dependent response of the extracellular matrix (ECM) proteins at the nanometer scale and the biophysical interactions between the ECM solid structure and interstitial fluid at the micrometer scale. The latter is governed by poroelasticity theory assuming free motion of the interstitial fluid within the porous ECM structure. In a recent study (Heris, H.K., Miri, A.K., Tripathy, U., Barthelat, F., Mongeau, L., 2013. J. Mech. Behav. Biomed. Mater.), atomic force microscopy was used to measure the response of porcine vocal folds to a creep loading and a 50-nm sinusoidal oscillation. A constitutive model was calibrated and verified using a finite element model to accurately predict the nanoscale viscoelastic moduli of ECM. A generally good correlation was obtained between the predicted variation of the viscoelastic moduli with depth and that of hyaluronic acids in vocal fold tissue. We conclude that hyaluronic acids may regulate vocal fold viscoelasticity. The proposed methodology offers a characterization tool for biomaterials used in vocal fold augmentations.
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U2 - 10.1016/j.jmbbm.2013.10.022
DO - 10.1016/j.jmbbm.2013.10.022
M3 - Article
C2 - 24317493
AN - SCOPUS:84889639418
SN - 1751-6161
VL - 30
SP - 196
EP - 204
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
ER -