@article{0abf79d263ad46e89ecafda6e5d7f26c,
title = "Multivascular networks and functional intravascular topologies within biocompatible hydrogels",
abstract = "Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.",
author = "Bagrat Grigoryan and Paulsen, {Samantha J.} and Corbett, {Daniel C.} and Sazer, {Daniel W.} and Fortin, {Chelsea L.} and Zaita, {Alexander J.} and Greenfield, {Paul T.} and Calafat, {Nicholas J.} and Gounley, {John P.} and Ta, {Anderson H.} and Fredrik Johansson and Amanda Randles and Rosenkrantz, {Jessica E.} and Louis-Rosenberg, {Jesse D.} and Galie, {Peter A.} and Stevens, {Kelly R.} and Miller, {Jordan S.}",
note = "Funding Information: This work was supported in part by the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation (J.S.M.), the U.S. National Science Foundation (NSF) (P.A.G., 1728239), an NSF Graduate Research Fellowship (B.G., 1450681), the U.S. National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) via F31 NRSA Fellowship (S.J.P., HL134295), the NIH Director{\textquoteright}s New Innovator Award (K.R.S., NHLBI, DP2HL137188), the John H. Tietze Foundation (K.R.S.), NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB) Cardiovascular Training Grant (D.C.C., T32EB001650); NIH National Institute of General Medical Sciences (NIGMS) Molecular Medicine Training Grant (C.L.F., T32GM095421); Office of the Director of the National Institutes of Health Early Independence Award (A.R., DP5OD019876), and a training fellowship from the Gulf Coast Consortia on the NSF IGERT: Neuroengineering from Cells to Systems (D.W.S., 1250104). The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2019",
month = may,
day = "3",
doi = "10.1126/science.aav9750",
language = "English (US)",
volume = "364",
pages = "458--464",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6439",
}